Effect of Compliance with Taking Antihypertensive Drug on Patient Quality of Life at Public Health Center Beji Batu


  • Rudy Mardianto ITSK RS dr. Soepraoen Malang
  • Beta Herilla Sekti ITSK RS dr. Soepraoen
  • Gezya Randra Higantara ITSK RS dr. Soepraoen



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Antihypertensive, compliance, quality of life


Hypertension is a disease characterized by an increase in blood pressure above normal. Hypertension can cause complications such as kidney failure resulting in morbidity and mortality. Compliance with taking antihypertensive drug is an important part of the success of the therapy for which there is expected to be an improvement in the patient's quality of life. This study aims to determine the effect of compliance with taking antihypertensive drug on patient quality of life at Public Health Center Beji Batu. It is quantitative observational research with a cross-sectional approach. The subjects were 34 outpatient hypertension patients who did not have comorbidities with the age of >17 and received antihypertensive drugs. The data were analyzed by the ordinal regression test using SPSS software version 26. The results show that the compliance with taking antihypertensive drugs level are 12 people comply (35.29%), 12 people less comply (35.29%) and 10 people discomply (29.41%). The results also show that the patient quality of life measurement are 0 people perfect (0%), 6 people very good (17.65%), 19 people good (55.88%), 9 people less good (26.47%), and 0 people death (0%). The results of the ordinal regression test show p value of 0.000<0.05 and R-square of 0.884. In conclusion, the compliance with taking antihypertensive drug affects the patient quality of life with p value of 0.000.


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American Academy of Family Physicians., C. (2014). JNC 8 Guidelines for The Management of Hypertension in Adult. American Family Physician, 90(7), 503–504. Retrieved from http://www.aafp.org/afp/2014/1001/p503.html

Andualem, A., Liknaw, T., Edmealem, A., & Gedefaw, M. (2021). Adherence to antihypertensive medications among adult hypertensive patients attending chronic follow-up units of Dessie Referral Hospital, Northeastern Ethiopia: A cross-sectional study. Medicine, 100(31), e26818. https://doi.org/10.1097/MD.0000000000026818

Arija, V., Villalobos, F., Pedret, R., Vinuesa, A., Jovani, D., Pascual, G., & Basora, J. (2018). Physical activity, cardiovascular health, quality of life and blood pressure control in hypertensive subjects: Randomized clinical trial 11 Medical and Health Sciences 1117 Public Health and Health Services 11 Medical and Health Sciences 1102 Cardiorespir. Health and Quality of Life Outcomes, 16(1), 1–11. https://doi.org/10.1186/s12955-018-1008-6

Burnier, M., & Egan, B. M. (2019). Adherence in Hypertension: A Review of Prevalence, Risk Factors, Impact, and Management. Circulation Research, 124(7), 1124–1140. https://doi.org/10.1161/CIRCRESAHA.118.313220

CDC. (2022). High Blood Pressure. Retrieved June 30, 2022, from Centers for disease Control and Prevention website: https://www.cdc.gov/bloodpressure/about.htm#hypertension

Chantakeeree, C., Sormunen, M., Estola, M., Jullamate, P., & Turunen, H. (2021). Factors Affecting Quality of Life among Older Adults with Hypertension in Urban and Rural Areas in Thailand: A Cross-Sectional Study. International Journal of Aging and Human Development, 1–23. https://doi.org/10.1177/00914150211050880

Dalal, J. J., Kerkar, P., Guha, S., Dasbiswas, A., Sawhney, J. P. S., Natarajan, S., … Reddi, R. (2021). Therapeutic adherence in hypertension: Current evidence and expert opinion from India. Indian Heart Journal, 73(6), 667–673. https://doi.org/10.1016/j.ihj.2021.09.003

De las Cuevas, C., & Peñate, W. (2015). Psychometric properties of the eight-item Morisky Medication Adherence Scale (MMAS-8) in a psychiatric outpatient setting. International Journal of Clinical and Health Psychology, 15(2), 121–129. https://doi.org/10.1016/j.ijchp.2014.11.003

Freeman, Starr, D. A., & O’connor. (2019). Prevention and Control of Hypertension: JACC Health Promotion Series. Am Coll Cardiol. https://doi.org/10.1016/j.jacc.2018.07.008.Prevention

Gavrilova, A., Bandere, D., Rutkovska, I., Šmits, D., Mauriņa, B., Poplavska, E., & Urtāne, A. I. (2019). Knowledge about Disease, Medication Therapy, and Related Medication Adherence Levels among Patients with Hypertension. Medicina (Kaunas, Lithuania), 55(11), 1–12. https://doi.org/10.3390/medicina55110715

JB, C. (2017). Hypertension in Obesity and the Impact of Weight Loss. Current Cardiology Reports, 19(10), 98. https://doi.org/10.1007/s11886-017-0912-4.HYPERTENSION

Kemenkes RI. (2018). Hasil Riset Kesehatan Dasar Tahun 2018. Kementrian Kesehatan RI, 53(9), 1689–1699.

Kemenkes RI. (2019). Hipertensi Penyakit Paling Banyak Diidap Masyarakat. Retrieved July 21, 2022, from https://www.kemkes.go.id/article/view/19051700002/hipertensi-penyakit-paling-banyak-diidap-masyarakat.html

Kurtul, S., Ak, F. K., & Türk, M. (2020). The prevalence of hypertension and influencing factors among the employees of a university hospital. African Health Sciences, 20(4), 1725–1733. https://doi.org/10.4314/ahs.v20i4.24

Li, J., Yu, J., Chen, X., Quan, X., & Zhou, L. (2018). Correlations between health-promoting lifestyle and health-related quality of life among elderly people with hypertension in Hengyang, Hunan, China. Medicine (United States), 97(25). https://doi.org/10.1097/MD.0000000000010937

Najjuma, J. N., Brennaman, L., Nabirye, R. C., Ssedyabane, F., Maling, S., Bajunirwe, F., & Muhindo, R. (2020). Adherence to antihypertensive medication: An interview analysis of southwest ugandan patients’ perspectives. Annals of Global Health, 86(1), 1–11. https://doi.org/10.5334/AOGH.2904

Nakane, Y., Tazaki, M., & Miyaoka, E. (1999). Whoqol. Iryo To Shakai, 9(1), 123–131. https://doi.org/10.4091/iken1991.9.1_123

Parra, D. I., Romero Guevara, S. L., & Rojas, L. Z. (2019). Influential factors in adherence to the therapeutic regime in hypertension and diabetes. Investigacion y Educacion En Enfermeria, 37(3). https://doi.org/10.17533/UDEA.IEE.V37N3E02

Peacock, E., Joyce, C., Craig, L. S., Lenane, Z., Holt, E. W., Muntner, P., & Krousel-Wood, M. (2021). Lowmedication adherence is associatedwith decline in health-related quality of life: Results of a longitudinal analysis among older women andmen with hypertension. Journal of Hypertension, 39(1), 153–161. https://doi.org/10.1097/HJH.0000000000002590

Ran, L., Li, M., Tan, X., & Chen, Q. (2021). Health-related quality of life of middle-aged and elderly people with hypertension: A cross-sectional survey from a rural area in China. PLoS ONE, 16(2 February), 1–13. https://doi.org/10.1371/journal.pone.0246409

Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter, N. R., Prabhakaran, D., … Schutte, A. E. (2020). 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension, 75(6), 1334–1357. https://doi.org/10.1161/HYPERTENSIONAHA.120.15026

Wang, C., Lang, J., Xuan, L., Li, X., & Zhang, L. (2017). The effect of health literacy and self-management efficacy on the health-related quality of life of hypertensive patients in a western rural area of China: A cross-sectional study. International Journal for Equity in Health, 16(1), 1–11. https://doi.org/10.1186/s12939-017-0551-9

WHO. (2022). Hypertension. Retrieved July 21, 2022, from https://www.who.int/health-topics/hypertension#tab=tab_1

Xu, T., Yu, X., Ou, S., Liu, X., Yuan, J., Tan, X., & Chen, Y. (2017). Adherence to Antihypertensive Medications and Stroke Risk: A Dose-Response Meta-Analysis. Journal of the American Heart Association, 6(7). https://doi.org/10.1161/JAHA.117.006371

Zheng, E., Xu, J., Xu, J., Zeng, X., Tan, W. J., Li, J., … Huang, W. (2021). Health-Related Quality of Life and Its Influencing Factors for Elderly Patients With Hypertension: Evidence From Heilongjiang Province, China. Frontiers in Public Health, 9(March), 1–8. https://doi.org/10.3389/fpubh.2021.654822

Zhou, B., Carrillo-Larco, R. M., Danaei, G., Riley, L. M., Paciorek, C. J., Stevens, G. A., … Zuñiga Cisneros, J. (2021). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. The Lancet, 398(10304), 957–980. https://doi.org/10.1016/S0140-6736(21)01330-1

Zhou, B., Perel, P., Mensah, G. A., & Ezzati, M. (2021). Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension. Nature Reviews Cardiology, 18(11), 785–802. https://doi.org/10.1038/s41569-021-00559-8



How to Cite

Mardianto, R., Sekti, B. H. ., & Higantara, G. R. . (2022). Effect of Compliance with Taking Antihypertensive Drug on Patient Quality of Life at Public Health Center Beji Batu. PHARMADEMICA : Jurnal Kefarmasian Dan Gizi, 2(1), 21–30. https://doi.org/10.54445/pharmademica.v2i1.21