PHARMADEMICA : Jurnal Kefarmasian dan Gizi 2022-03-31T00:00:00+07:00 apt. Dr. Bilal Subchan Agus S. M.Farm. Open Journal Systems <p><strong>PHARMADEMICA : Jurnal Kefarmasian dan Gizi</strong> is an Open Access Scientific Journal published by LPPMKI - AKAFARMA AKFAR PIM. <strong>PHARMADEMICA : Jurnal Kefarmasian dan Gizi</strong> publishes original research article in all areas of :</p> <ol> <li>Clinical Pharmacy</li> <li>Pharmaceutical Chemistry</li> <li>Pharmaceutics</li> <li>Community Pharmacy</li> <li>Pharmacognosy</li> <li>Phytochemistry</li> <li>Pharmaceutical Analysis</li> <li>Pharmacy Education and Learning</li> <li>Biochemistry</li> <li>Clinical Nutrition</li> <li>Community Nutrition</li> <li>Functional Foods</li> </ol> <p><strong>PHARMADEMICA : Jurnal Kefarmasian dan Gizi</strong> accepts submissions all year round. Editorial board receives the articles from the educators, observers, researchers to be published after having selection, peer review, and serious editing. This journal publishes a manuscript written in Indonesian, twice a year in March and September.</p> Analysis of Retinoic Acid Content on Night Whitening Cosmetic Cream in Malang City 2022-03-08T09:15:34+07:00 Fendi Yoga Wardana Yunida Senja Lestari Rakhmadani Gadis Aprilianti <p><em>Whitening cream is a product that is used on the outside of the body to lighten or change the color of the skin. Whitening cream contains chemicals that are harmful to the skin, such as mercury, hydroquinone, and retinoic acid. Retinoic acid belongs to a group of drugs that are prohibited because it can cause dry skin, burning and teratogenicity. Therefore, it is necessary to analyze the retinoic acid in whitening cream. This study aims to determine the content of retinoic acid in night whitening cream. The samples in this study were 5 night whitening cream products marketed in Malang. Qualitative test of retinoic acid was performed by Thin Layer Chromatography (TLC) with silica gel 60F 254 nm as a stationary phase and n-hexane: acetone (6:4) as a mobile phase, and quantitative test using UV-Vis spectrophotometry. The observation result on TLC shows dark blue spots when viewed under UV light at 254 nm with Rf values for samples B, D, and E of 0.487; sample C of 0.425; while the Rf value of the comparison standard is 0.500. The quantitative test indicates 4 samples of night whitening cream contain retinoic acid; 0.165% in sample B, 0.060% in sample C, 0.125% in sample D, and 0.151% in sample E. In conclusion, samples B, C, D and E do not meet the BPOM requirements because they are sold freely without a doctor's supervision.</em></p> 2022-03-25T00:00:00+07:00 Copyright (c) 2022 Fendi Yoga Wardana, Yunida Senja Lestari, Rakhmadani Gadis Aprilianti Antioxidant Potency of Combination Extract of Water-Ethanol in Selada Air (Nasturtium officinale R. Br) Simplisia 2022-03-04T13:08:12+07:00 Karina Tria Amanda Sentot Joko Raharjo <p><em>Empirically, </em><em>selada air</em><em> has a potency as a vegetable rich in antioxidants, but there has been no study of the antioxidant activity potency of selada air simplisia maceration with water-ethanol combination solvent. This study aims to determine the optimization of yield and antioxidant activity (IC<sub>50</sub> value) of selada air simplisia maceration using ethanol-water combination solvent. The method of this research is the determination of the yield and IC<sub>50</sub> value using the DPPH method from the maceration of selada air using a water-ethanol combination solvent (96, 70, 30 and 0%). The yields of selada air simplisia maceration with water-ethanol combination solvent (96, 70, 30 and 0%) are 9.25±1.62%, 15.63±1.25%, 23.63±2.38% and 19.99±3.82%. The IC<sub>50</sub> values ​​are 613.77±1.90 ppm, 190.892±5.41 ppm, 350.78±1.77 ppm, and 2418.59±137.80 ppm. In conclusion, the optimal yield of maceration result is shown by the water-ethanol combination solvent of 30% (23.63%) and the optimal IC<sub>50</sub> value is shown by the water-ethanol combination solvent of 70% (190.892 ppm).</em></p> 2022-03-24T00:00:00+07:00 Copyright (c) 2022 Karina Tria Amanda, Sentot Joko Raharjo Identification of Salicylic Acid Content in Anti-Acne Cream Products at Tajinan Market Malang Regency 2022-03-08T08:30:03+07:00 Fendi Yoga Wardana Nurul Fadila Mayang Aditya Ayuning Siwi <p><em>Anti-acne cream is a type of cosmetics that is often used for skin care. Salicylic acid is often used as the active substance in this anti-acne cream. According to the Indonesian National Food and Drug Agency in 2019 on cosmetics, salicylic acid is allowed in cosmetics if it is not more than 2%.</em> <em>In this study, 6 types of anti-acne cream, from Tajinan Market, Malang Regency, were tested with the aim of studying the content of salicylic acid in anti-acne cream products. The test was performed qualitatively using a colour test with FeCl<sub>3</sub> reagent (a positive reaction show a purple colour) and a thin layer chromatography (TLC) method using a solvent mixture of ethyl acetate;methanol;ammonia (8:1.90:0.10) as the mobile phase. Quantitative determination of the content was performed using UV-Vis spectrophotometry. The qualitative test with the colour test indicates that samples A and E are positive for containing salicylic acid. The results of the thin layer chromatography (TLC) test indicates that sample A is positive for containing salicylic acid with an Rf value of 0.66, which is the same as the comparison standard. The quantitative test with UV-Vis spectrophotometry indicates that the salicylic acid content in sample A is 2.516%, sample D is 1,400%, and sample E is 1.646%. In conclusion, only cream of sample A do not meet the requirements of the Indonesian National Food and Drug Agency because it has a salicylic acid content of more than 2%.</em></p> 2022-03-25T00:00:00+07:00 Copyright (c) 2022 Fendi Yoga Wardana, Nurul Fadila, Mayang Aditya Ayuning Siwi Level of Compliance with the Use of Oral Antidiabetes Drugs in DM Patients at Rampal Support Hospital (Rumkitban) Malang 2022-03-05T08:05:44+07:00 Mayang Aditya Ayuning Siwi Dzikrina Ilmanita Merischa Shelviana Chahyaning Dias <p><em>Diabetes Mellitus is a chronic condition that occurs due to the increased level of glucose in the blood. There are 10.70 million Indonesian people who have been diagnosed with diabetes, so Indonesia is ranked 7th among 10 countries with the highest number of diabetes sufferers. In long-term diseases such as diabetes mellitus, the compliance of drug use is one of the determinants for the success of therapy. This study aims to observe at the description of the use of oral antidiabetes drugs in DM patients at the Rampal Assistance Hospital, Malang. This research is descriptive research with a cross section approach. Data were collected using a Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire of 30 respondents. Data analysis was performed statistically, presented in the form of a percentage. Based on the results of the study, the level of compliance on the use of oral antidiabetes drugs at Rumkitban Rampal on April 2021 is 3 respondents (10%) of low compliance, 16 respondents (53.33%) of moderate compliance and 11 respondents (36.67%) of high compliance. Characteristics of patients that have a significant relationship with the level of compliance are the level of education, employment status, and the presence or absence of comorbidity. While the patient's age, gender, length of suffering and number of drugs used do not have a significant relationship with the level of compliance.</em></p> <p><strong>Keywords</strong>: <em>oral antidiabetic, diabetes mellitus, adherence level</em></p> 2022-03-24T00:00:00+07:00 Copyright (c) 2022 Mayang Aditya Ayuning Siwi, Dzikrina Ilmanita, Merischa Shelviana Chahyaning Dias Prescribing Pattern of Breast Cancer Chemotherapy Drugs at Lavalette Hospital Malang 2022-03-15T12:15:29+07:00 Irawati Irawati Mardhiyah Sardjan <p><em>Breast cancer is one type of malignant diseases with a high incidence both in Indonesia and in the world. It is the number one killer in Indonesia. Chemotherapy, as a method used in the breast cancer treatment, causes side effects that can interfere the quality of life of breast cancer patients. This study aims to determine the type of chemotherapy drugs, the combination of chemotherapy drugs in a prescription, and the dose of chemotherapy drugs at Lavalette Hospital. This study is descriptive research. It was conducted by collecting 100 sheets of breast cancer chemotherapy prescriptions in November 2020 as samples. Findings specify that the types of chemotherapy drugs for breast cancer that are often prescribed are cyclophosphamide 29%, docetaxel 19% and paclitaxel 17%. Combination of chemotherapy drugs that is often written down is the combination of 2 drugs of TdC (docetaxel cyclophosphamide) 36% and TpCar (paclitaxel, carboplatin) 33%. The dose writing for all types of drugs has been reviewed according to the patients’ weight, height and age.</em></p> 2022-03-28T00:00:00+07:00 Copyright (c) 2022 Irawati Irawati, Mardhiyah Sardjan