Identification of Off-Label Drug Use in Geriatric Patients with Degenerative Diseases at Sugio Health Center
DOI:
https://doi.org/10.54445/pharmademica.v5i2.111
Abstract View:
8
PDF downloads:
0
Keywords:
degenerative, geriatric, off label, sugio health centerAbstract
Prescribing medications that do not comply with the official information stated on the drug label and marketing authorization, such as dose, age, route of administration, contraindications, and indications, is known as off-label drug use. Elderly patients may experience undesirable adverse effects due to off-label medication use. This study aimed to evaluate off-label drug use among elderly individuals with degenerative diseases at Sugio Primary Health Center. This study collected data retrospectively from the medical records of elderly patients with degenerative disorders at Sugio Primary Health Center using a descriptive non-experimental design. The sample was selected using a purposive sampling method. The inclusion criteria were geriatric patients aged ≥60 years diagnosed with degenerative diseases who received outpatient care during the period of January–August 2024. Data were collected using an observation sheet and analyzed using univariate analysis. The findings from 150 patients showed that 69 (46%) were categorized as off-label dose and 58 (38.7%) as off-label age. These findings indicate that off-label drug use still occurs among elderly patients, highlighting the need to evaluate the rationality of prescribing practices.
Downloads
References
Agustiningrum, R., Handayani, S., & Hermawan, A. (2021). Hubungan Status Gizi dengan Penyakit Degeneratif Kronik pada Lansia di Puskesmas Jogonalan I. Urecol Journal. Part D: Applied Sciences, 1(1), 33–34. https://doi.org/10.53017/ujas.52
Amala, D. (2018). Identifikasi Penggunaan Obat Off Label Pada Pasien Geriatri Rawat Inap di Rumah Sakit Umum Pusat dr. Sardjito. Skripsi Universitas Muhammadiyah Yogyakarta.
Association, A. P. (2015). Drug Information Handbook With International Trade Names Index 23rd Edition. Ohio: Lexicomp.
Awali, J. D., Pardilawati, C. Y., Soleha, T. U., & Oktarlina, R. Z. (2024). Kajian Polifarmasi Terhadap Keamanan Obat Pada Pasien Geriatri. Medula, 14(4), 739–745.
BPS. (2023). Profil Penduduk Lanjut Usia Provinsi Jawa Timur 2023. Badan Pusat Statistik.
British Medical Association, & Britain, R. P. S. of G. (2019). BNF 78 (Biritsh National Formulary). In BNF 78 (Biritsh National Formulary) (Issue 1051).
Dera, C. F. A., & Nurma, S. (2022). Off-label Medication Use in Pediatric Outpatients: A Retrospective Observational Study at Dr. H. Abdul Moeloek Hospital in Lampung. Indonesian Journal of Clinical Pharmacy, 11(2), 116–128. https://doi.org/10.15416/ijcp.2022.11.2.116
Febriyanti, A. P., Atmaja, R. R. D., Oktaviani, H. C., & Wijaya, D. (2023). Analisis Peresepan Polifarmasi Pada Pasien Geriatri dengan Diabetes Melitus Tipe 2 Berdasarkan Beers Criteria 2023. Jurnal Mandala Pharmacon Indonesia, 9(2), 613–620. https://doi.org/10.35311/jmpi.v9i2.423
Hafsah, Hasria, A., Hastuti, & Sri, Y. M. (2022). Peningkatan Pengetahuan Tentang Penyakit Degeneratif Pada Masyarakat Petani Desa Laliko Sulawesi. Journal Of Community Empowerment, 1, 63–71.
Kemenkes RI. (2015). Permenkes No. 67 Tahun 2015 Tentang Penyelenggaraan Pelayanan Kesehatan Lanjut Usia Di Pusat Kesehatan Masyarakat. In Kementerian Kesehatan Indonesia.
Lahmudin, R. R., Bina, U., & Gorontalo, M. (2024). Studi Literatur Profil Farmakokinetik Obat Anti Inflamasi Nonsteroid Pada Populasi Geriatri Literature Study on Pharmacokinetic Profiles of Nonsteroidal Anti-Inflammatory Drugs in Geriatric. 4(1), 84–95.
Lubis, N. D., & Astuti, S. D. (2021). Penggunaan Off-Label Drug Pada Pasien Geriatri Dengan Penyakit Degeneratif Di Apotek Wilayah Surakarta. Jurnal Farmasi Indonesia, 18(1), 32–40. https://doi.org/10.31001/jfi.v18i1.642
Mulyani, T., & Rukminingsih, F. (2020). Evaluasi Peresepan Pada Pasien Geriatri Di Klinik Penyakit Dalam Instalasi Rawat Jalan Rsud K . R . M . T Evaluation of Prescription At Geriatric Patients Based on the Beers Criteria 2015 At the Internal Medicine Clinic in the Outpatient Installation of. Jurnal Riset Kefarmasian Indonesia, 2(2), 89–96.
Oktariani S., M. D. S. (2017). Perbedaan Efek Pemberian Air Rebusan Daun Mindi (Melia Azedarach L) Terhadap Penurunan Tekanan Darah Pada Pasien Hipertensi Esensial Dan Hipertensi Non Esensial Di Kelurahan Kadipiro Kecamatan Banjarsari Kota Surakarta. Jurnal Kesehatan Kusuma Husada, Vol. 8 No. 1, Januari 2017, 91–97.
Selano, M., Nono, E. A., & Handayani, K. P. (2024). Skrining Kesehatan Dan Edukasi Pencegahan Penyakit Degeneratif Pada Kelompok Lansia. Jurnal Pengabdian Kepada Masyarakat (JPKM) - Aphelion, 4, 171–178.
Setyaningrum, N., Gredynadita, V., & Gartina, S. (2017). Penggunaan Obat Off-Label pada Anak di Apotek Kota Yogyakarta. Jurnal Sains Farmasi & Klinis. https://doi.org/10.29208/jsfk.2017.4.1.169
Shakeel, S., Iffat, W., Qamar, A., Nesar, S., & Butt, F. (2022). Assessment of Knowledge , Attitude , and Practice of Obstetricians and Gynecologists Toward Off-Label Medicine Use in Female Reproductive Health Issues. 10(March), 1–10. https://doi.org/10.3389/fpubh.2022.829339
Society, A. G. (2023). a Pocket Guide To The 2023 AGS Beers Criteria. The American Geriatrics Society, 1.
Sumardiyono, S., Lowa, N. W., Azzam, A. M., Huda, K. N., & Nurfauziah, N. (2017). Kejadian Myalgia pada Lansia Pasien Rawat Jalan. Jrst: Jurnal Riset Sains Dan Teknologi, 1(2), 59. https://doi.org/10.30595/jrst.v1i2.1442
Wang, J., Jiang, F., Yang, Y., Zhang, Y., Liu, Z., Qin, X., Tao, X., Liu, T., Liu, Y., Tang, Y., Liu, H., & Cotes, R. O. (2021). Off-label use of antipsychotic medications in psychiatric inpatients in China : a national real-world survey. 1–9.
Yakaryilmaz, F. D., & Ozturk, Z. A. (2017). Treatment Of Type 2 Diabetes Mellitus In The Elderly. WJD (World Journal Of Diabetes), 8 (6), 278–285.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Berliana Putri Nabella, Irma Susanti, Devi Ristian Octavia
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
.png)
