PHARMADEMICA : Jurnal Kefarmasian dan Gizi

Differences In Destruction Time and Determination of Generic and Trademark Paracetamol Tablets Using UV Spectrophotometry Method

2023-10-31T20:59:29+07:00

Paracetamol is one of the most widely used antipyretic analgesic drugs in the community. Paracetamol in circulation, both generic and trademarked, is generally given in the form of tablets containing 500 mg of the active ingredient. At this time people prefer to use trademarked paracetamol tablets with the assumption that trademarked drugs are more efficacious than generic drugs. This study aims to determine the difference in disintegration time and content of generic paracetamol tablets with trademarks. The study was conducted on 2 samples of generic paracetamol tablets with 2 samples of paracetamol tablets of different brands. The results of the disintegration time test showed that the average of generic A paracetamol tablets was 8.41 minutes, generic B 1.2 minutes, trademark A 2.14 minutes, trademark B 1.2 minutes. While the results of the average level test obtained paracetamol tablets generic A 109.87% generic B 105.95% trademark A 103.28% trademark B 92.49% with categories according to the standards set in the literature. The results of the Paired Sample T-test on disintegration time obtained a value of 0.006 and the results on the level test of 1.00 so that it can be concluded that between generic and trademarked paracetamol tablets only have differences in disintegration time with the same concentration.

Physical Quality and Stability of Body Scrub Preparation Salak Pondoh Fruit Extract (Salacca edulis Reinw.) with Emulgator of Stearic Acid and Triethanolamine

2023-10-02T10:00:14+07:00

Salak pondoh fruit contains flavonoids that can be used to counteract free radicals. These flavonoids act as antioxidants which can regenerate dead skin cells, so salak pondoh fruit can be used as a body scrub. This research aims to determine the physical quality and stability of body scrub preparations from salak pondoh fruit extract with stearic acid and triethanolamine as emulgators. It is an experimental study with a single group design. The amount of salak pondoh fruit extract used in body scrubs was 0,1%. The physical quality testing carried out includes organoleptics, homogeneity, dispersality, pH, viscosity, and emulsion type, while for the physical stability testing, the cycling test method was used, including the storage method in a refrigerator with a temperature of 4ºC and storage method in an oven with a temperature of 40ºC for 6 cycles or 12 days. Based on the physical quality test result, the body scrub is white, semi-solid, distinctive aromatic odor, homogeneous, with a pH value of 6,00, a dispersion power of 4.71 cm, a viscosity of 9095 cps, and an emulsion type of O/W. The physical stability test results indicate that the body scrub is qualified on all tests (organoleptic, homogeneity, pH, emulsion type, viscosity, and dispersion). The analysis with a paired sample t-test shows a value of >0.05 for the dispersion, pH, and viscosity tests. It can be concluded that the body scrub preparation meets the requirements and retains its stability in storage.

Analysis of The Relationship Between Response Time for Conditioning and Non-Mission Drug Prescription with Patient Satisfaction at Jambu Kulon Health Centre

2023-09-30T21:28:11+07:00

One of the causes of patients at the health centre feeling uncomfortable with the drug administration process is the problem of waiting time. Patient satisfaction is strongly influenced by waiting time indicators for health centre prescription services. Patient satisfaction will increase if the service time is faster, especially the time spent waiting for the drug. This study aims to determine the average waiting time for concocted and non-concocted prescription services, patient satisfaction levels, and the relationship between waiting time for concocted and non-concocted prescription services and patient satisfaction at the Jambu Kulon Health Centre, Klaten District. This research is a quantitative correlation with a cross sectional approach. The sampling technique was accidental sampling with a sample of 60 respondents. Collecting data and information on respondents using a valid questionnaire with a minimum value range of 0.422 to a maximum of 0.751 and a Cronbach’s Alpha value of 0.926. The results of the significant value obtained for concoction recipes p = 0.142 and non-cooking p = 0.702, while the correlation value of the Spearman test (r) for prescription drug -0.274 and nonprescription drug -0.073 indicates that the direction of the correlation is negative or the direction of the relationship is opposite, indicating that there is an inverse of proportionality between the two variables. The conclusion is that patient satisfaction and waiting time for prescription services are statistically not significantly correlated (p>0.05).

The Adherence Level of Hypertension Patients in Taking Medication at The BMCI Malang Clinic

2023-10-02T09:53:10+07:00

High blood pressure, also known as hypertension, is a disease that is not contagious and seems to High blood pressure, also known as hypertension, is a disease that is not contagious and has been increasing in Indonesia over the years. It is a significant cause of illness and death, particularly in relation to stroke, along with smoking and a history of heart disease. In fact, up to 70% of stroke patients have hypertension. In Malang City, hypertension is one of the most prevalent diseases, with a total of 35,641 cases. The key to effective hypertension management is ensuring compliance with antihypertensive medication, which is primarily done at First Level Health Facilities (FKTP). Therefore, this study aimed to evaluate compliance levels among hypertensive patients who are registered with the Chronic Disease Management Program (PROLANIS) at the BMCI Malang Clinic. A descriptive cross-sectional method was used, and medication adherence questionnaires were administered using the Morisky Medication Adherence Scale (MMAS-8). The study found that 60% of hypertensive patients were between the ages of 56 and 65, 60% were female, and 64% had a low level of education. Based on their characteristics, more than half of the respondents had a moderate level of compliance.

Effect of Simplicia Storage Temperature on the Curcumin Concentration of Temugiring (Curcuma heyneana Val.) Rhizome Simplicia

2023-08-09T12:36:06+07:00

The storage temperature of temugiring (Curcuma heyneana Val.) rhizome simplicia affects the curcumin active compound concentration in simplicia. This research aims to determine the effect of simplicia storage temperature on the curcumin compound concentration in temugiring rhizome simplicia. This is experimental research by various storage temperature of simplicia at 4, 15, 28, 37, and 40 ⁰C for a month. Simplicia extraction was conducted by maceration method using ethanol 95% as a solvent with the ratio of simplicia powder and the solvent of 1:8. Determination of curcumin concentration was conducted by the UV-Vis spectrophotometry method at a wavelength of 420 nm. Data analysis was conducted by the one-way anova testing. Findings show that the highest to lowest curcumin concentration are at 28⁰C of 51.360 ± 5.298 ppm, at 4⁰C of 50.046 ± 5.177 ppm, at 15⁰C of 42.000 ± 2.745 ppm, at 37⁰C of 28.885 ± 4.155 ppm, and at 40⁰C of 26.314 ± 4.843 ppm. In conclusion, the storage temperature affects the curcumin concentration of temugiring rhizome simplicia.

Temperatur penyimpanan simplisia rimpang temugiring (Curcuma heyneana Val.) mempengaruhi kandungan senyawa aktif kurkumin pada simplisia. Penelitian ini bertujuan untuk mengetahui pengaruh temperatur penyimpanan simplisia terhadap kadar senyawa kurkumin pada simplisia rimpang temugiring. Metode penelitian meliputi penyimpanan simplisia rimpang temugiring pada temperatur dingin (4⁰C), sejuk (15⁰C), ruangan (28⁰C), panas (37⁰C), dan sangat panas (40⁰C) selama satu bulan. Ekstraksi simplisia dilakukan dengan metode maserasi menggunakan pelarut etanol 95% dengan perbandingan serbuk simplisia dan pelarut adalah 1:8. Penentuan kadar kurkumin dilakukan dengan metode spektrofotometri UV-Vis pada panjang gelombang 420 nm. Hasil penelitian menunjukkan kadar kurkumin tinggi pada temperatur penyimpanan ruangan (28⁰C) sebesar 51,360 ± 5,298 ppm, dingin (4⁰C) sebesar 50,046 ± 5,177 ppm, dan sejuk (15⁰C) sebesar 42,000 ± 2,745 ppm. Kadar kurkumin rendah pada temperatur penyimpanan panas (37⁰C) sebesar 28,856 ± 4,155 ppm, dan sangat panas (40⁰C) sebesar 26,314 ± 4,843 ppm. Hal ini menunjukkan bahwa temperatur penyimpanan berpengaruh terhadap kadar kurkumin simplisia rimpang temugiring.